5-(Benzyloxycarbonylamino)pyridine-3-boronic acid, pinacol ester
benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ylcarbamate
CAS: 1218790-11-4
Molecular Formula: C19H23BN2O4
5-(Benzyloxycarbonylamino)pyridine-3-boronic acid, pinacol ester - Names and Identifiers
| Name | benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ylcarbamate |
| Synonyms | benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridi... 5-(Benzyloxycarbonylamino)pyridine-3-boronic acid, pinacol ester benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ylcarbamate Benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinylcarbamate benzyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamate Carbamic acid, N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-, phenylmethyl ester |
| CAS | 1218790-11-4 |
| InChI | InChI=1S/C19H23BN2O4/c1-18(2)19(3,4)26-20(25-18)15-10-16(12-21-11-15)22-17(23)24-13-14-8-6-5-7-9-14/h5-12H,13H2,1-4H3,(H,22,23) |
5-(Benzyloxycarbonylamino)pyridine-3-boronic acid, pinacol ester - Physico-chemical Properties
| Molecular Formula | C19H23BN2O4 |
| Molar Mass | 354.21 |
| Storage Condition | 2-8°C |
5-(Benzyloxycarbonylamino)pyridine-3-boronic acid, pinacol ester - Introduction
3-(Cbz-amino) pyridine-5-boronic acid pinacol ester, often abbreviated as Boc-PyBOP, is an organic compound with certain properties and uses.
Nature:
1. Appearance: colorless or light yellow solid.
2. molecular formula: C15H23BN2O5.
3. molecular weight: 332.17.
4. melting point: about 163-166 ℃.
Use:
Boc-PyBOP is commonly used as an amine activator, used for pyridine substrate carboxyl protection and amine reaction occasions, commonly used in the synthesis of peptide compounds. In addition, Boc-PyBOP can also be used to synthesize biologically active small molecule compounds.
Preparation Method:
1. First, pyridine-5-boronic acid pinacol ester and dimethylformamide (DMF) were dissolved in methyl chloride to obtain a DMF compound of pyridine-5-boronic acid pinacol ester.
2. reacting CBZ-amino (Cbz-NH2) with the Boc-PyBOP DMF compound in diethyl carbonate to generate 3-(Cbz-amino) pyridine-5-boronic acid pinacol ester.
3. Filtration and crystallization give the product.
Safety Information:
The following safety measures should be taken during use:
1. Boc-PyBOP may be irritating to the skin, eyes and mucous membranes, direct contact should be avoided.
2. Wear appropriate protective glasses, gloves and protective clothing during operation.
3. the operation process should maintain good ventilation conditions.
4. Avoid inhaling or ingesting Boc-PyBOP.
5. Comply with regulations and precautions for chemicals when using or handling.
Please note that chemical operations should be carried out under the guidance of professionals to ensure safety and correctness.
Nature:
1. Appearance: colorless or light yellow solid.
2. molecular formula: C15H23BN2O5.
3. molecular weight: 332.17.
4. melting point: about 163-166 ℃.
Use:
Boc-PyBOP is commonly used as an amine activator, used for pyridine substrate carboxyl protection and amine reaction occasions, commonly used in the synthesis of peptide compounds. In addition, Boc-PyBOP can also be used to synthesize biologically active small molecule compounds.
Preparation Method:
1. First, pyridine-5-boronic acid pinacol ester and dimethylformamide (DMF) were dissolved in methyl chloride to obtain a DMF compound of pyridine-5-boronic acid pinacol ester.
2. reacting CBZ-amino (Cbz-NH2) with the Boc-PyBOP DMF compound in diethyl carbonate to generate 3-(Cbz-amino) pyridine-5-boronic acid pinacol ester.
3. Filtration and crystallization give the product.
Safety Information:
The following safety measures should be taken during use:
1. Boc-PyBOP may be irritating to the skin, eyes and mucous membranes, direct contact should be avoided.
2. Wear appropriate protective glasses, gloves and protective clothing during operation.
3. the operation process should maintain good ventilation conditions.
4. Avoid inhaling or ingesting Boc-PyBOP.
5. Comply with regulations and precautions for chemicals when using or handling.
Please note that chemical operations should be carried out under the guidance of professionals to ensure safety and correctness.
Last Update：2024-04-10 22:29:15
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Product Name: benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-ylcarbamate Visit Supplier Webpage Request for quotation
CAS: 1218790-11-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1218790-11-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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